153898-63-6, name is 2-Iodo-5-methoxyaniline, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C7H8INO
Example 76(b) 2,2,2-Trifluoro-N-(2-iodo-5-methoxy-phenyl)-acetamide To a solution of 2-iodo-5-methoxy-phenylamine 76a (4.05 g, 16.3 mmole) in 10 ml anhydrous CH2Cl2 was added TFAA (4.1 g, 19.5 mmole). The mixture was stirred at 36 C. overnight, TLC indicated some starting material remained. Additional TFAA (4.1 g, 19.5 mmole) was added and stirred at 38 C. for another 24 hours. The mixture was concentrated under rot vap and purified by column chromatography (eluding with 5-10% EtOAc in hexanes) to give 4.6 g product (81% yield). 1H NMR (300 MHz, CDCl3) delta7.92 (1H, d, J=2.8 Hz), 7.66 (1H, d, J=8.9 Hz), 6.59 (1H, dd, J=2.8, 8.9 Hz), 3.82 (3H, s).
The synthetic route of 153898-63-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Agouron Pharmaceuticals, Inc.; US2004/9965; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com