Related Products of 624-76-0, The chemical industry reduces the impact on the environment during synthesis 624-76-0, name is 2-Iodoethanol, I believe this compound will play a more active role in future production and life.
To a solution of carbazole 1 (2.0 g, 11.96 mmol) in distilled DMF (20 mL) was added NaH (60% dispersion in mineral oil, 956.9 mg, 23.92 mmol) under nitrogen condition and stirred at 0 C for 30 min. To the reaction mixture was added dropwise 2-iodoethanol (4.1 g, 23.92 mmol) and stirred at 70 C for 24 h. The mixture was extracted with EtOAc and washed with water and dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent, n-hexane/ EtOAc = 3:1) to afford 1.64 g (7.84 mmol , 65%) of the title compound 2.: Rf = 0.18 (n-hexane/EtOAc = 2:1); IR (neat, cm-1) 3253, 3048, 2914, 1492, 1483, 1457, 1348, 1325; 1H NMR d (400 MHz, CDCl3) d 8.07 (2H, td, J = 7.6, 1.2 Hz), 7.44-7.39 (4H, m), 7.22 (2H, td, J = 7.6, 1.2 Hz), 4.38 (2H, t, J = 5.2 Hz); 13C NMR (100 MHz, CDCl3) d 140.9, 126.0, 123.1, 120.6, 119.4, 109.0, 61.6, 45.6.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodoethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Jin, Guo Hua; Lee, Hwa Jin; Gim, Hyo Jin; Ryu, Jae-Ha; Jeon, Raok; Bioorganic and Medicinal Chemistry Letters; vol. 22; 9; (2012); p. 3301 – 3304;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com