These common heterocyclic compound, 689260-53-5, name is 2-Bromo-5-iodo-1,3-dimethylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H8BrI
5.5 g (17.8 mmol) 2-Bromo-5-iodo-1 ,3-dimethylbenzene, 6.5 g (12.7 mmol) EG1 , 366 mg (0.3 mmol) tetrakis(triphenylphosphin)-palladium(0) and 2.7 g (13 mmol) sodium carbonate are dissolved in 200 ml toluene, ethanol and water (2:1 :1 ) and stirred for 16 hours at 90 C. After cooling down to room temperature 100 ml toluene are added, the organic phase is separated and washed with water (2×50 ml). The organic phase is concentrated to dryness under reduced pressure. The residue is purified by recrystallization from toluene/heptane. Yield: 6.2 g (11 mmol; 86 %)
The synthetic route of 2-Bromo-5-iodo-1,3-dimethylbenzene has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK PATENT GMBH; LINGE, Rouven; MEYER, Sebastian; LACKNER, Aaron; HEIL, Holger; KOENEN, Nils; (168 pag.)WO2019/101833; (2019); A1;,
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