Application of 20555-91-3,Some common heterocyclic compound, 20555-91-3, name is 1,2-Dichloro-4-iodobenzene, molecular formula is C6H3Cl2I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a mixture of CuI (95.2 mg, 0.50 mmol), CsF (91.1 mg, 0.60 mmol), 4-iodobenzonitrile (1a,114.0 mg, 0.50 mmol), and THF (1.0 mL) was added [(trimethylsilyl)difluoromethyl]phosphonate (2,156.2 mg, 0.60 mmol) at room temperature. The reaction mixture was stirred at 60 C in an atmosphere of nitrogen for 24 h and quenched with water. The aqueous layer was extracted with ethyl acetate.Then, the combined organic phase was washed with water, dried over anhydrous Na2SO4. The crude product was purified by column chromatography on silica gel (hexane/EtOAc = 2/1) to give 3a(121.4 mg, 0.42 mmol, 84%) as a pale-yellow oil.
The synthetic route of 20555-91-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Komoda, Kazuki; Iwamoto, Rei; Kasumi, Masakazu; Amii, Hideki; Molecules; vol. 23; 12; (2018);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com