Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64248-58-4, name is 1,2-Difluoro-4-iodobenzene, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H3F2I
Add bis (triphenylphosphine) palladium (II) dichloride (49 mg, 0. 07 mmol), copper (I) iodide (28 mg, 0. 15 mmol), and 3-chloro-5-ethynylpyridine, (prepared as described in PREPARATION 27), (200 mg, 1. 5 mmol) to a solution of 1, 2-difluoro-4-iodobenzene (420 mg, 1. 7 mmol) in triethylarnine (3. 1 mL, 22 mmol) and heat at 60 C for 16 h. Cool to room temperature and concentrate. Purify the residue by silica gel chromatography, eluting with a gradient of 50 : 50 to 100 : 0 dichloromethane : hexanes, followed by a second silica gel chromatography, eluting with 95 : 5 to 85 : 15 hexanes : ethyl acetate to give the title compound as a white solid (320 mg, 88%). 1H NMR (300 MHz, Cd13) 8 7. 14-7. 23 (m, 1H), 7. 28-7. 40 (m, 2H), 7. 76-7. 82 (t, J = 2. 0 Hz, 1H), 8. 51-8. 55 (d, J = 2. 3 Hz, 1H), 8. 59-8. 62 (d, J = 1. 8 Hz, 1H), MS (APCI) : m/z= 250 [M+H] +.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 64248-58-4.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/94822; (2005); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com