In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 98-61-3, name is 4-Iodobenzenesulfonyl chloride belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 98-61-3
A solution of (tetrahydro-2-furanylmethyl)amine (0.167 g, 1.65 mmol) and triethylamine (0.35 ml, 2.48 mmol) in dichloromethane (10 ml) was stirred in an ice/water bath with stirring under argon, and then 4-iodobenzenesulfonyl chloride (0.500 g, 1.65 mmol) was added dropwise with stirring. The resulting mixture was allowed to stir at room temperature for 16 hours. Then the solution was washed with water, organic layer separated, dried with sodium sulphate and the solvent was removed by rotary evaporation to give the title compound as a white solid (0.596 g, 98%).1H-NMR (400 MHz, CDCl3) delta: 7.87 (2H, m), 7.57 (2H, m), 4.81 (1H, m), 3.91 (1H, m), 3.77 (1H, m), 3.70 (1H, m), 3.13 (1H, m), 2.88 (1H, m), 1.98-1.84 (3H, m), 1.58 (1H, m); LC/MS Retention time 2.70 mins/(ES+) 368 (M+H, C11H14INO3S requires 367).
The synthetic route of 98-61-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; US2010/137276; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com