3058-39-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3058-39-7, name is 4-Iodobenzonitrile, A new synthetic method of this compound is introduced below.
Example 3; Preparation of Organic Compound by Using Silicon-Based Cross-Coupling Reagents 1a to 1i of the Present Invention; The silicon-based cross-coupling reagents 1a to 1i of the present invention were used to carry out cross coupling reaction with an organic halide I-R10, thereby preparing various kinds of organic compounds. Table 1 shows reaction times, yields, a silicon-based cross-coupling reagent R1 used and an organic halide R10. Note that, in Table 1, product numbers correspond to the numbers of the following substances respectively.; Any one of the silicon-based cross-coupling reagents 1a to 1i (1.1 mmol) and the organic halide (1.0 mmol) were sequentially added to a mixture of K2CO3 (304 mg, 2.2 mmol), tri-2-furilic phosphine (4.6 mg, 20 mumol), and PdCl2 (1.8 mg, 10 mumol) in DMSO (2.5 mL), and the resulting mixture was stirred at 35¡ã C. When each of the times shown in Table 1 had passed, the resulting mixture was diluted with diethyl ether and was washed with water and brine, and then was dried over anhydrous MgSO4. After concentration under reduced pressure, the residue was purified by flash chromatography on silica gel, thereby obtaining organic compounds p1 to p24 which were cross-coupling products respectively corresponding to yields shown in Table 1. The following shows chemical formulas and characteristic data of the resultant organic compounds p1 to p22 and p24.
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Reference:
Patent; Nakao, Yoshiaki; Hiyama, Tamejiro; US2009/69577; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com