Synthetic Route of 460-37-7,Some common heterocyclic compound, 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, molecular formula is C3H4F3I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a tubular reactor, evacuated and replaced twice with nitrogen, and 10 ml of methyl tert-butyl ether solvent was added under a nitrogen atmosphere.1 mmol of the compound of the above formula (II),2mmol of the above formula iodide compound,2.5 mmol of azide trimethylsilane,2mmol tert-butyl peroxybenzoateAnd 0.02 mmol of a copper hexafluorophosphate tetraacetonitrile catalyst is dissolved in the above solvent,The reaction was stirred at a temperature of 30 C for 2 hours. After the reaction was completed, the reaction liquid was cooled to room temperature, filtered, and the solvent was evaporated under reduced pressure.Purification of the compound of formula III by column chromatography,The yield was 92.7%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,1,1-Trifluoro-3-iodopropane, its application will become more common.
Reference:
Patent; Zhang Haiying; Zhou Lanlan; (12 pag.)CN108440503; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com