Related Products of 5326-47-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5326-47-6, name is 2-Amino-5-iodobenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 2-amino-5-iodobenzoicacid (17) (15 mmol, 4.0 g) in methanol(16 mL) was added concentrated H2SO4 (3.0 mL). Thereaction mixture was refluxed for 6 h and stirred at room temperature for additional12h. After removal of the solvent, the residue was poured into 100 mL saturatedNaHCO3 solution and extracted with ethyl acetate(3¡Á15 mL). The organic layer was separated, washed with brine (3¡Á15 mL), driedover anhydrous Na2SO4, filteredand concentrated to give the product methyl 2-amino-5-iodobenzoate (18) as yellow solid, Yield: 94%, mp:70-73C. 1H NMR (400 MHz, DMSO-d6, ppm) delta: 8.13 (1H,d, J = 2.16 Hz), 7.47 (1H, dd, J = 8.68, 2.16 Hz), 6.45 (1H, d, J = 8.72 Hz), 5.42 (2H, s, NH2),3.86 (3H, s, O-CH3). C8H8INO2.
The synthetic route of 2-Amino-5-iodobenzoic acid has been constantly updated, and we look forward to future research findings.
Reference:
Article; Kang, Dongwei; Zhang, Heng; Zhou, Zhongxia; Huang, Boshi; Naesens, Lieve; Zhan, Peng; Liu, Xinyong; Bioorganic and Medicinal Chemistry Letters; vol. 26; 21; (2016); p. 5182 – 5186;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com