Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 59528-27-7, name is (4-Iodophenyl)methanamine hydrochloride, A new synthetic method of this compound is introduced below., Formula: C7H9ClIN
General procedure: The aldehyde (1 mmol) and 4-iodobenzylamine hydrochloride (0.270 g, 1 mmol) were mixed with dry DCE (25 mL). If indicated, TEA (139 muL, 1 mmol) was added to liberate the parent amine. Next, Na(AcO)3BH (0.318 g, 1.5 mmol) was added and the mixture was stirred at rt for 24-36 h. Aq NaOH-soln (2 M) was added and the mixture was stirred vigorously for 10 min, after which DCM was added. The organic layer was separated and the aq layer was back-extracted with DCM (1¡Á). The combined organic layers were dried (Na2SO4), filtered and concentrated. If required, the crude product was purified by column chromatography.
The synthetic route of 59528-27-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wijtmans, Maikel; Verzijl, Dennis; Bergmans, Serge; Lai, Michael; Bosch, Leontien; Smit, Martine J.; De Esch, Iwan J.P.; Leurs, Rob; Bioorganic and Medicinal Chemistry; vol. 19; 11; (2011); p. 3384 – 3393;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com