Adding a certain compound to certain chemical reactions, such as: 5458-84-4, name is 1-Iodo-2-methoxy-4-nitrobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5458-84-4, Product Details of 5458-84-4
3- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) pyridin-2-amine (20 g, 91 mmol)1-iodo-2-methoxy-4-nitrobenzene (23 g, 83 mmol)Pd (PPh 3) 4 (1 g, 0.83 mmol) and sodium carbonate (26 g, 248 mmol) were added to DME (300 mL) and water (200 mL)After sufficiently degassing the reaction mixture,And the mixture was heated under reflux for 16 hours.The reaction was cooled to room temperature,It was partitioned between EtOAc and water.The layers were separated,The aqueous layer was extracted twice with EtOAc.The combined organic layers were dried over sodium sulfate,Filtered,It was rotary evaporated.The crude material was washed with EtOAc,5.0 g of product was obtained.The filtrate was chromatographed on silica gel (1/1 hexane / EtOAc to EtOAc)A further 4.4 g of product was obtained.The total yield of 3- (2-methoxy-4-nitrophenyl) pyridin-2-amine was 9.4 g (46%).
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Reference:
Patent; UNIVERSAL DISPLAY CORPORATION; XIA, CHUANJUN; LIN, CHUN; KOTTAS, GREGG; ELSHENAWY, ZEINAB; (78 pag.)JP6216571; (2017); B2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com