In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 146137-72-6 as follows. Recommanded Product: 146137-72-6
General procedure: To a solution of the aldehyde 1aev (1 eq.) in tert-butanol(9.0 ml/mmol) the diamine (1.1 eq.)was added and the solutionwasstirred at 70 C for 30 min K2CO3 (4 eq.) and I2 (1.25 eq.) was addedat 70 C and the mixture was stirred at this temperature for further3 h. The mixture was cooled down to rt and Na2S2O3 was addeduntil the iodine color almost disappear. The organic layer wasseparated and the solvent was removed in vacuo. The received solid was dissolved in water (7.5 ml/mmol) and 2 N NaOHaq was addeduntil pH 12e14. The aqueous layer was separated with CHCl3(3 3.75 ml/mmol), the combined organic layers were dried(Na2SO4) and the solvent was removed in vacuo. The product can beused without further purification.
According to the analysis of related databases, 146137-72-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Wolff, Benjamin; Jaensch, Niklas; Sugiarto, Wisely Oki; Fruehschulz, Stefan; Lang, Maraike; Altintas, Rabia; Oehme, Ina; Meyer-Almes, Franz-Josef; European Journal of Medicinal Chemistry; vol. 184; (2019);,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com