Application of 42861-71-2, The chemical industry reduces the impact on the environment during synthesis 42861-71-2, name is 3-Iodophenyl acetate, I believe this compound will play a more active role in future production and life.
Intermediate- 17: 3-(Trimethylsilanylethynyl)-phenylacetate; To a solution of 3-acetoxy iodobenzene (6.0 g, 22.89 mmoles) in DMSO (25 mL) was added trimethylsilyl acetylene (1.1 eq) followed by triethylamine (3 eq), CuI (0.05 eq) and tetrakis (triphenylphosphine) palladium(O) (0.03 eq) and the reaction’ mixture was stirred at room temperature for 6 h. The reaction mixture was then diluted with water and extracted with ethyl acetate. The organic layer was then dried over Na2SO4, concentrated and purified by column chromatography to get 4.3 g of the desired product. 1H NMR (CDCl3) delta 7.30-7.25 (m, 2H), 7.18 (s, IH), 7.05-6.95 (m, IH), 2.28 (s, 3H), 0.24 (s, 9H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodophenyl acetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; GHARAT, Laxmikant, Atmaram; NARAYANA, Lakshminarayana; THOMAS, Abraham; KHAIRATKAR-JOSHI, Neelima; SHAH, Daisy, Manish; WO2010/7482; (2010); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com