Related Products of 401-81-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 401-81-0, name is 1-Iodo-3-(trifluoromethyl)benzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To a resealable Schlenk tube, was added Cs2CO3 (2.0mmol), KSCN (1.5mmol) and MCM-41-2N-CuCl (110mg, 0.05mmol), and the reaction vessel was fitted with a rubber septum. The vessel was evacuated and back-filled with argon and this evacuation/back-fill procedure was repeated one additional time. The aryl iodide (1.0mmol) and water (3mL) were then added under a stream of argon. The reaction tube was quickly sealed and the contents were stirred while heating in an oil bath at 130C for 48h. After completion of the reaction, the reaction mixture was cooled to room temperature, extracted with ethyl acetate (3¡Á5mL), and filtered. The MCM-41-2N-CuCl complex was washed with distilled water (2¡Á5mL), ethyl acetate (2¡Á5mL), and Et2O (2¡Á5mL) and reused in the next run. The extract was concentrated under reduced pressure and the residue was purified by flash column chromatography on silica gel (petroleum/ethyl acetate=50:1 to 10:1) to provide the desired product.
The synthetic route of 1-Iodo-3-(trifluoromethyl)benzene has been constantly updated, and we look forward to future research findings.
Reference:
Short Survey; Cai, Mingzhong; Xiao, Ruian; Yan, Tao; Zhao, Hong; Journal of Organometallic Chemistry; vol. 749; (2014); p. 55 – 60;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com