Copper catalyzed cyanation through C=C bond cleavage of gem-aryl dibromide followed by second cyanation of iodoarene by a released CN unit was written by Maity, Pintu;Kundu, Debasish;Ghosh, Tubai;Ranu, Brindaban C.. And the article was included in Organic Chemistry Frontiers in 2018.SDS of cas: 5460-32-2 This article mentions the following:
A new approach for the synthesis of aryl cyanides through C=C cleavage of styrenyl gem-dibromide via an in situ cyanation process by sodium azide in the presence of CuO nanoparticles and simultaneous intermol. cyanation of an iodoarene by capturing a released CN unit has been achieved. Several diversely substituted aryl/heteroaryl cyanides including a precursor to etravirine, a drug for the treatment of HIV, have been obtained by this procedure. This protocol is unique with regard to cyanation without a cyanide reagent and provides access to two different nitriles in one reaction involving full utilization of CN units. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2SDS of cas: 5460-32-2).
4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.SDS of cas: 5460-32-2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com