Iodine(III)-Mediated, Controlled Di- or Monoiodination of Phenols was written by Satkar, Yuvraj;Yera-Ledesma, Luisa F.;Mali, Narendra;Patil, Dipak;Navarro-Santos, Pedro;Segura-Quezada, Luis A.;Ramirez-Morales, Perla I.;Solorio-Alvarado, Cesar R.. And the article was included in Journal of Organic Chemistry in 2019.Application In Synthesis of 4-Bromo-2-iodophenol This article mentions the following:
An oxidative procedure for the electrophilic iodination of phenols was developed by using iodosylbenzene as a nontoxic iodine(III)-based oxidant and ammonium iodide as a cheap iodine atom source. A totally controlled monoiodination was achieved by buffering the reaction medium with K3PO4. This protocol proceeds with short reaction times, at mild temperatures, in an open flask, and generally with high yields. Gram-scale reactions, as well as the scope of this protocol, were explored with electron-rich and electron-poor phenols as well as heterocycles. Quantum chem. calculations revealed PhII(OH)璺疦H3 to be the most plausible iodinating active species as a reactive “I+” synthon. In light of the relevance of the iodoarene moiety, we present herein a practical, efficient, and simple procedure with a broad functional group scope that allows access to the iodoarene core unit. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Application In Synthesis of 4-Bromo-2-iodophenol).
4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Application In Synthesis of 4-Bromo-2-iodophenol
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com