Acyl Cyanides as Bifunctional Reagent: Application in Copper-Catalyzed Cyanoamidation and Cyanoesterification Reaction was written by Chen, Zhengwang;Wen, Xiaowei;Zheng, Weiping;He, Ruolan;Chen, Dou;Cao, Dingsheng;Long, Lipeng;Ye, Min. And the article was included in Journal of Organic Chemistry in 2020.Electric Literature of C6H5FIN This article mentions the following:
Cu-catalyzed domino decyanation and cyanation reaction of acyl cyanides with amines or alcs. was developed. The cyano sources were generated in situ via C-CN cleavage yielding the corresponding cyano substituted amides RC(O)NHR1 [R = Ph, 3-MeC6H4, 4-CNC6H4, etc.; R1 = H, 3-CNC6H4, (CH2)2Ph, etc.] or esters RC(O)OR2 [R2 = Me, Ph, 2-CNC6H4, etc.] in moderate to excellent yields. This approach featured a cheap copper catalyst, domino decyanation and cyanation reaction, readily available starting materials, broad substrate scope, operational simplicity and the potential for further transformation of the cyano group. In the experiment, the researchers used many compounds, for example, 3-Fluoro-5-iodoaniline (cas: 660-49-1Electric Literature of C6H5FIN).
3-Fluoro-5-iodoaniline (cas: 660-49-1) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Electric Literature of C6H5FIN
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com