Month: February 2023

A General Approach to Optically Pure [5]-, [6]-, and [7]Heterohelicenes was written by Zadny, Jaroslav;Jancarik, Andrej;Andronova, Angelina;Samal, Michal;Vacek Chocholousova, Jana;Vacek, Jaroslav;Pohl, Radek;Saman, David;Cisarova, Ivana;Stara, Irena G.;Stary, Ivo. And the article was included in Angewandte Chemie, International Edition in 2012.COA of Formula: C6H4BrIO This article mentions the following:

A general method for the preparation of optically pure [5]-, [6]-, and [7]heterohelicenes is based on a Co^I– or Ni⁰-catalyzed diastereoselective [2+2+2] cycloisomerization of centrally chiral triynes to deliver helicenes containing two 2H-pyran rings. The configuration, which can be predicted, does not depend on helicene length or functional groups present. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8COA of Formula: C6H4BrIO).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.COA of Formula: C6H4BrIO

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Molybdenum-Mediated Carbonylation of Aryl Halides with Nucleophiles Using Microwave Irradiation was written by Roberts, Bryan;Liptrot, David;Alcaraz, Lilian;Luker, Tim;Stocks, Michael J.. And the article was included in Organic Letters in 2010.SDS of cas: 77350-52-8 This article mentions the following:

A new, efficient, and practical molybdenum-mediated carbonylation of aryl and heteroaryl halides with a variety of nucleophiles is described using microwave irradiation A range of reactions illustrating the wide scope of this chem. were carried out and proceeded in good to excellent yields. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8SDS of cas: 77350-52-8).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.SDS of cas: 77350-52-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Evolution of N-Heterocycle-Substituted Iodoarenes (NHIAs) to Efficient Organocatalysts in Iodine(I/III)-Mediated Oxidative Transformations was written by Boelke, Andreas;Nachtsheim, Boris J.. And the article was included in Advanced Synthesis & Catalysis in 2020.Electric Literature of C7H4ClIO2 This article mentions the following:

The reactivity of ortho-functionalized N-heterocycle-substituted iodoarenes (NHIAs) as organocatalysts in iodine(I/III)-mediated oxidations was systematically investigated in the α-tosyloxylation of ketones as the model reaction. During a systematic catalyst evolution, it was found that NH-triazoles and benzoxazoles have the most significant pos. influence on the reactivity of the central iodine atom. A further catalyst improvement which focused on the substitution pattern of the arene revealed a remarkable ortho-effect. By introduction of an o-OMe group we were able to generate a novel NHIA with a so far unseen catalytic efficiency. This new catalyst is not only easy to synthesize but also enabled the α-tosyloxylation of carbonyl compounds at the lowest reported catalyst loading of only 1 mol%. Finally, the performance of this iodine(I) catalyst was successfully demonstrated in intramol. oxidative couplings of biphenyls and oxidative rearrangements. In the experiment, the researchers used many compounds, for example, 3-Chloro-2-iodobenzoic acid (cas: 123278-03-5Electric Literature of C7H4ClIO2).

3-Chloro-2-iodobenzoic acid (cas: 123278-03-5) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Electric Literature of C7H4ClIO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Catalytic, Diastereoselective 1,2-Difluorination of Alkenes was written by Banik, Steven M.;Medley, Jonathan William;Jacobsen, Eric N.. And the article was included in Journal of the American Chemical Society in 2016.Recommanded Product: 338454-02-7 This article mentions the following:

We describe a direct, catalytic approach to the 1,2-difluorination of alkenes. The method utilizes a nucleophilic fluoride source and an oxidant in conjunction with an aryl iodide catalyst and is applicable to alkenes with all types of substitution patterns. In general, the vicinal difluoride products are produced with high diastereoselectivities. The observed sense of stereoinduction implicates anchimeric assistance pathways in reactions of alkenes bearing neighboring Lewis basic functionality. In the experiment, the researchers used many compounds, for example, Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7Recommanded Product: 338454-02-7).

Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Recommanded Product: 338454-02-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Pd-catalyzed cross-electrophile Coupling/C-H alkylation reaction enabled by a mediator generated via C(sp³)-H activation was written by Wu, Zhuo;Jiang, Hang;Zhang, Yanghui. And the article was included in Chemical Science in 2021.COA of Formula: C8H7IO2 This article mentions the following:

Pd-catalyzed cascade cross-electrophile coupling and C-H alkylation reaction of 2-iodo-alkoxylarenes with alkyl chlorides were reported. Methoxy and benzyloxy groups, which were ubiquitous functional groups and common protecting groups, were utilized as crucial mediators via primary or secondary C(sp³)-H activation. The reaction provided an innovative and convenient access for the synthesis of alkylated phenol derivatives, which were widely found in bioactive compounds and organic functional materials. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6COA of Formula: C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons–Smith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.COA of Formula: C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Nickel-catalyzed carbonylative synthesis of dihydrobenzofurans was written by Geng, Hui-Qing;Wang, Wei;Wu, Xiao-Feng. And the article was included in Catalysis Communications in 2021.Name: 1-Chloro-4-iodobutane This article mentions the following:

A nickel-catalyzed carbonylative synthesis of dihydrobenzofurans has been developed. With Mo(CO)6 as the CO source and manganese metal as the reductant, alkyl halides were reacted with aryl iodides to give the desired products in moderate to good yields. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Name: 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Name: 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Anti-selective [3+2] (Hetero)annulation of non-conjugated alkenes via directed nucleopalladation was written by Ni, Hui-Qi;Kevlishvili, Ilia;Bedekar, Pranali G.;Barber, Joyann S.;Yang, Shouliang;Tran-Dube, Michelle;Romine, Andrew M.;Lu, Hou-Xiang;McAlpine, Indrawan J.;Liu, Peng;Engle, Keary M.. And the article was included in Nature Communications in 2020.Product Details of 207115-22-8 This article mentions the following:

A method that enables direct access to these core structures, e.g., I from non-conjugated alkenyl amides RNHC(O)CH(R²)CH=CHR¹ [R = quinolin-8-yl, pyridin-2-yl; R¹ = H, Me, Et; R² = H, CH₃, CH₂C₆H₅, 3-CH₃OC₆H₄(CH₂)₂, (CH₂)₂OCH₂C₆H₅, (CH₂)₂CH=CH₂] and N-3-buten-1-yl-2-pyridinecarboxamide and ortho-iodoanilines, e.g., 4-iodopyridin-3-amine/phenols II (R³ = Me, Br, t-Bu, etc.; R⁴ = H, Br; R⁵ = H, I; X = O) has been described. Under palladium(II) catalysis this [3 + 2] heteroannulation proceeds in an anti-selective fashion and tolerates a wide variety of functional groups. N-Acetyl, -tosyl, and -alkyl substituted ortho-iodoanilines, as well as free -NH₂ variants, are all effective. Preliminary results with carbon-based coupling partners like Et 2-cyano-2-(2-iodophenyl)acetate, di-Me 2-(2-iodophenyl)malonate and Et 2-(benzenesulfonyl)-2-(2-iodophenyl)acetate also demonstrate the viability of forming indane core structures III (R⁶ = C(O)₂Me, C(O)₂Et; R⁷ = C(O)₂Me, CN, S(O)₂Ph) using this approach. Exptl. and computational studies on reactions with phenols support a mechanism involving turnover-limiting, endergonic directed oxypalladation, followed by intramol. oxidative addition and reductive elimination. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Product Details of 207115-22-8).

4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Product Details of 207115-22-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

m-Iodosylbenzoic acid – a convenient recyclable reagent for highly efficient aromatic iodinations was written by Kirschning, Andreas;Yusubov, Mekhman S.;Yusubova, Roza Y.;Chi, Ki-Whan;Park, Joo Y.. And the article was included in Beilstein Journal of Organic Chemistry in 2007.Computed Properties of C8H7IO2 This article mentions the following:

M-Iodosylbenzoic acid is used to perform iodination of arenes in the presence of iodine at room temperature in acetonitrile. Separation of pure products is conveniently achieved by scavenging any aryl iodide by ion exchange with IRA-900 (hydroxide form). The reduced form of the reagent, m-iodobenzoic acid, can be easily recovered from the ion exchange resin or from the basic aqueous solution by simple acidification with HCl. In the experiment, the researchers used many compounds, for example, 3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6Computed Properties of C8H7IO2).

3-Iodo-4-methoxybenzaldehyde (cas: 2314-37-6) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Computed Properties of C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Liquid crystals for IR: Part II synthesis and properties of perfluoroalkyl- or perfluoroalkoxy-terminated tolanes was written by Harmata, Piotr;Herman, Jakub;Kula, Przemyslaw. And the article was included in Liquid Crystals in 2020.COA of Formula: C6H3F2I This article mentions the following:

Several homologous series of laterally halogenated and perfluoroalkyl- or perfluoroalkoxy-terminated tolanes derivatives were synthesized. Obtained compounds were divided into three families, i.e. tolanes, phenyltolanes, bistolanes and their mesomorphic properties, phase transition temperatures and enthalpies were determined The influence of the length of the core, type and position of substituents in the mol. core has been analyzed. The lack of aliphatic protons in mol. structure generates unique IR properties of presented materials and their mixtures In the experiment, the researchers used many compounds, for example, 1,2-Difluoro-3-iodobenzene (cas: 64248-57-3COA of Formula: C6H3F2I).

1,2-Difluoro-3-iodobenzene (cas: 64248-57-3) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.COA of Formula: C6H3F2I

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Zeolites Catalyze the Nazarov Reaction and the tert-Butylation of Alcohols by Stabilization of Carboxonium Intermediates was written by Tejeda-Serrano, Maria;Sanz-Navarro, Sergio;Blake, Finn;Leyva-Perez, Antonio. And the article was included in Synthesis in 2020.SDS of cas: 877264-43-2 This article mentions the following:

Here, it shows that representative carboxonium-mediated organic reactions, such as Nazarov cyclization and tert-butylation of alcs. C₆H₅CCC(OH)(R¹)R² (R¹ = Ph, R² = H; R¹ = R² = Ph; R¹ = R² = H) with tert-Bu acetate, typically performed with very strong acid catalysts in solution such as triflic acid, can be catalyzed by simple zeolites with high yield and selectivity. The aluminosilicate framework stabilizes the intermediate carboxonium species and overrides the need for superacid protons in solution Zeolites are the most used catalysts worldwide in petrochem. processes, with particular ability to stabilize carbocations. However, the use of zeolites in organic synthesis is still scarce. In the experiment, the researchers used many compounds, for example, (5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2SDS of cas: 877264-43-2).

(5-Fluoro-2-iodophenyl)methanol (cas: 877264-43-2) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.SDS of cas: 877264-43-2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com