Month: February 2023

Photo-induced and electronic properties of soluble rigid-rod polyimides was written by Tomikawa, Masao. And the article was included in Recent Research Developments in Polymer Science in 1998.Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene This article mentions the following:

A series of fluoroalkyl-substituted pyromellitic dianhydrides were synthesized from 1,2,4,5-tetramethyl-benzene (durene). Soluble rigid-rod polyimides were obtained from the dianhydrides and 4,4′-Diamino-2,2′-bis(trifluoromethyl)biphenyl (PFMB) in phenolic solvents in the presence of isoquinoline catalyst. The polyimides are soluble in N-methyl-2-pyrrolidone (NMP), N,N-dimethylacetamide (DMAc), m-cresol, and other polar solvents, in spite of their rigid-rod structure. UV irradiation induced color changes of the polyimide solutions A new absorption band appeared in the 700 nm region and an ESR signal emerged upon UV-irradiation which are attributed to the anion radical of the diimide moiety in the polyimide, as deduced from the hyperfine structure of the ESR signal. The same radical was detected by electrochem. confirming that the radical was generated by photoinduced charge transfer reaction. The UV-irradiation also causes a decrease in the solution viscosity and this change is reversible. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Safety of 1,4-Diiodo-2,3,5,6-tetramethylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Mn-Mediated Coupling of Alkyl Iodides and Chiral N-Acylhydrazones: Optimization, Scope, and Evidence for a Radical Mechanism was written by Friestad, Gregory K.;Marie, Jean-Charles;Suh, YoungSung;Qin, Jun. And the article was included in Journal of Organic Chemistry in 2006.Product Details of 10297-05-9 This article mentions the following:

Stereoselective radical additions have excellent potential as mild, nonbasic carbon-carbon bond constructions for direct asym. amine synthesis. Efficient intermol. radical addition to C:N bonds with acyclic stereocontrol has previously been limited mainly to secondary and tertiary radicals, a serious limitation from the perspective of synthetic applications. Here, we provide full details of the use of photolysis with manganese carbonyl to mediate stereoselective intermol. radical addition to N-acylhydrazones. Photolysis (300 nm) of alkyl halides and hydrazones in the presence of Mn₂(CO)₁₀ and InCl₃ as a Lewis acid led to reductive radical addition; diastereomer ratios ranged from 93:7 to 98:2 at ca. 35 鎺矯. The reaction tolerates addnl. functionality in either reactant, enabling subsequent transformations as shown in an efficient asym. synthesis of coniine. A series of hydrazones bearing different substituents on the oxazolidinone auxiliary were compared; consistently high diastereoselectivity revealed that the identity of the substituent had little practical effect on the diastereoselectivity. Further mechanistic control experiments confirmed the intermediacy of radicals and showed that independently prepared alkyl- or acyl manganese pentacarbonyl compounds do not undergo efficient addition to the N-acylhydrazones under thermal or photolytic (300 nm) conditions. These Mn-mediated conditions avoid toxic tin reagents and enable stereoselective intermol. radical additions to C:N bonds with the broadest range of alkyl halides yet reported, including previously ineffective primary alkyl halides. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Product Details of 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Product Details of 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Chemoselective Coupling of 1,1-Bis[(pinacolato)boryl]alkanes for the Transition-Metal-Free Borylation of Aryl and Vinyl Halides: A Combined Experimental and Theoretical Investigation was written by Lee, Yeosan;Baek, Seung-yeol;Park, Jinyoung;Kim, Seoung-Tae;Tussupbayev, Samat;Kim, Jeongho;Baik, Mu-Hyun;Cho, Seung Hwan. And the article was included in Journal of the American Chemical Society in 2017.HPLC of Formula: 77350-52-8 This article mentions the following:

A new transition-metal-free borylation of aryl and vinyl halides using 1,1-bis[(pinacolato)boryl]alkanes as boron sources is described. In this transformation one of the boron groups from 1,1-bis[(pinacolato)boryl]alkanes is selectively transferred to aryl and vinyl halides in the presence of sodium tert-butoxide as the only activator to form organoboronate esters. Under the developed borylation conditions, a broad range of organohalides are borylated with excellent chemoselectivity and functional group compatibility, thus offering a rare example of a transition-metal-free borylation protocol. Exptl. and theor. studies have been performed to elucidate the reaction mechanism, revealing the unusual formation of Lewis acid/base adduct between organohalides and 浼?borylcarbanion, generated in situ from the reaction of 1,1-bis[(pinacolato)boryl]alkanes with an alkoxide base, to facilitate the borylation reactions. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8HPLC of Formula: 77350-52-8).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.HPLC of Formula: 77350-52-8

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Convergent syntheses of 2,3-dihydrobenzofurans via a Catellani strategy was written by Wu, Chenggui;Cheng, Hong-Gang;Chen, Ruiming;Chen, Han;Liu, Ze-Shui;Zhang, Jingyang;Zhang, Yuming;Zhu, Yuxin;Geng, Zhi;Zhou, Qianghui. And the article was included in Organic Chemistry Frontiers in 2018.Formula: C8H7IO2 This article mentions the following:

A cooperative catalytic system comprising a Pd/XPhos complex and a potassium salt of 5-norbornene-2-carboxylic acid to promote the annulation between aryl iodides and epoxides was developed, thereby providing highly convergent access to valuable 2,3-dihydrobenzofuran (DHBF) scaffolds. The unique potassium salt of the inexpensive 5-norbornene-2-carboxylic acid serves as a highly efficient catalytic mediator (10 mol%), which leads to fewer side reactions. The salient features of the reaction include its broad substrate scope (with respect to both aryl iodides and epoxides), its high atom economy and good chemo-selectivity. Furthermore, no extra base is needed for the process. In the experiment, the researchers used many compounds, for example, 3-Iodo-2-methylbenzoic acid (cas: 133232-56-1Formula: C8H7IO2).

3-Iodo-2-methylbenzoic acid (cas: 133232-56-1) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Formula: C8H7IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

One-Pot Preparation of Alkyl Iodides from Esters by Indium-Catalyzed Reductive Cleavage of a Carbon-Oxygen Bond was written by Sakai, Norio;Matsushita, Yohei;Konakahara, Takeo;Ogiwara, Yohei;Hirano, Keisuke. And the article was included in European Journal of Organic Chemistry in 2015.Category: iodides-buliding-blocks This article mentions the following:

The indium-catalyzed reductive iodination of aliphatic and aromatic esters with iodine and 1,1,3,3-tetramethyldisiloxane (TMDS) was described. The reducing procedure accommodates a variety of esters, including esters containing alkyl groups, halogens, a hydroxy group, a thioether, and an alkene moiety. This procedure was applied to the cleavage of carbon-oxygen bonds in acrylate polymers. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9Category: iodides-buliding-blocks).

1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Azoles. Part 4. Nucleophilic substitution reactions of haloimidazoles was written by Iddon, Brian;Khan, Nazir;Lim, Bee Lan. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1987.Synthetic Route of C3H2I2N2 This article mentions the following:

A number of N-protected derivatives of 2,4,5-tribromoimidazole, 4-bromo-5-nitroimidazole, and 2,4-dibromo-5-nitroimidazole were prepared by standard procedures and treated with various nucleophiles. Whereas 2,4,5-tribromo (and tri-iodo)imidazole reacted with PhSNa to give 4,5-dihaloimidazoles, 1-protected derivatives of 2,4,5-tribromoimidazole reacted with RSNa (R = Et, Pr, Ph, PhCH₂) in Me₂CHOH, by displacement of the 2-bromine atom. 1-Benzyl-5-bromo-4-nitroimidazole, 2-(5-bromo-4-nitroimidazol-1-yl) acetate, and 5-bromo-4-nitro-1-phenacylimidazole (I) reacted by displacement of the 5-bromine atom. The product arising from reaction of I with HSCH₂CO₂Et in EtOH in the presence of base, cyclized to give imidazothiazine II. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Synthetic Route of C3H2I2N2).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Synthetic Route of C3H2I2N2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Photoredox relay-catalyzed gem-difluoroallylation of alkyl iodides was written by Guo, Yuanqiang;Cao, Yunpeng;Song, Hongjian;Liu, Yuxiu;Wang, Qingmin. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.SDS of cas: 10297-05-9 This article mentions the following:

Herein, a new example of relay catalysis, using a combination of Mn₂(CO)₁₀ and an iridium-based photocatalyst, is reported. In this relay catalytic reaction, the Mn catalyst and iridium-based photocatalyst catalyze the reaction at different stages in the desired sequence under the same reaction conditions, and do not inhibit each other. This convenient method transforms a broad scope of alkyl iodides RI (R = iso-Pr, cyclopentyl, 4-methoxyphenethyl, morpholino, etc.) into the corresponding gem-difluoroalkenes R¹C(=CF₂)CH₂R (R¹ = Ph, 2-naphthyl, pyridin-3-yl, etc.) via C(sp³)-C(sp³) bond construction. The protocol has good functional group tolerance and is suitable for the late-stage modification of multifunctional complex mols. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9SDS of cas: 10297-05-9).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.SDS of cas: 10297-05-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A Domino Approach of Heck Coupling for the Synthesis of 灏?Trifluoromethylstyrenes was written by Prakash, G. K. Surya;Krishnan, Hema S.;Jog, Parag V.;Iyer, Anjali P.;Olah, George A.. And the article was included in Organic Letters in 2012.HPLC of Formula: 3268-21-1 This article mentions the following:

A domino approach of Heck coupling was used to synthesize 灏?trifluoromethylstyrene derivatives from iodoarenes and 1-iodo-3,3,3-trifluoropropane in moderate to good yields. This method avoids the use of low-boiling, gaseous reagents such as 3,3,3-trifluoropropene, and additives and phosphines in the catalytic system. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1HPLC of Formula: 3268-21-1).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.HPLC of Formula: 3268-21-1

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

A Putative Single-Photon Emission CT Imaging Tracer for Erythropoietin-Producing Hepatocellular A2 Receptor was written by Furukawa, Takenori;Kimura, Hiroyuki;Torimoto, Hanae;Yagi, Yusuke;Kawashima, Hidekazu;Arimitsu, Kenji;Yasui, Hiroyuki. And the article was included in ACS Medicinal Chemistry Letters in 2021.Synthetic Route of C6H4INO2 This article mentions the following:

Erythropoietin-producing hepatocellular (Eph) receptors are receptor tyrosine kinases involved in cell-cell contact. The EphA2 receptor is associated with cancer proliferation and migration. Therefore, EphA2 receptor imaging has the potential for cancer diagnosis. Here, we synthesized N-(5-((4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)carbamoyl)-2-methylphenyl)-5-[¹²³I]iodonicotinamide ([¹²³I]ETB) and evaluated it as an imaging tracer for single-photon emission computed tomog. (SPECT) imaging of the EphA2 receptor. [¹²³I]ETB was designed on the basis of ALW-II-41-27, an inhibitor of EphA2 receptor kinase. Nonradioactive ETB was also synthesized and has been shown to efficiently inhibit EphA2 receptor kinase activity in vitro (IC₅₀: ETB, 90.2 鍗?18.9 nM). A cell-binding assay demonstrated that [¹²⁵I]ETB binds specifically to the EphA2 receptor. The ex vivo biodistribution study of [¹²⁵I]ETB in U87MG tumor-bearing mice also revealed tumor uptake (2.2% ID/g at 240 min). In addition, [¹²³I]ETB uptake in tumors was visualized via SPECT/CT imaging. On the basis of the above, [¹²³I]ETB can be considered a potential SPECT imaging tracer for the EphA2 receptor. In the experiment, the researchers used many compounds, for example, 5-Iodonicotinic acid (cas: 15366-65-1Synthetic Route of C6H4INO2).

5-Iodonicotinic acid (cas: 15366-65-1) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C閳ユ彂 bond. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Synthetic Route of C6H4INO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Four-Component Supramolecular Nanorotors was written by Samanta, Soumen K.;Schmittel, Michael. And the article was included in Journal of the American Chemical Society in 2013.Formula: C10H12I2 This article mentions the following:

A family of supramol. four-component nanorotors was quant. self-assembled from two different Zn(II) porphyrins: one representing the stator and the other the rotator with DABCO as an interconnecting axle and Cu(I) ions. Rotational spinning in ROT-1′ occurs at 97,000 s^-1 at 25鎺?but is virtually stopped at -75鎺? The activation vs. binding data suggest that spinning is an intrasupramol. process occurring to >99.9% without dissociation Addition and removal of two further equiv of Cu⁺ reversibly switches the mode of the stochastic rotation between pure 180鎺?and mixed 90鎺?180鎺?steps and reversibly regulates the speed between 97,000 and 閳?0,000 s^-1. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Formula: C10H12I2).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Formula: C10H12I2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com