Month: February 2023

A one-pot radioiodination of aryl amines via stable diazonium salts: preparation of ¹²⁵I-imaging agents was written by Sloan, Nikki L.;Luthra, Sajinder K.;McRobbie, Graeme;Pimlott, Sally L.;Sutherland, Andrew. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2017.Electric Literature of C6H3ClINO2 This article mentions the following:

An operationally simple, one-pot, two-step tandem procedure was described which allowed the incorporation of radioactive iodine [¹²⁵I] into aryl amines to yield radioiodine labeled arenes, e.g., I via stable diazonium salts formation. The mild conditions were tolerant of various functional groups and substitution patterns, allowing late-stage, rapid access to a wide range of ¹²⁵I-labeled aryl compounds and SPECT radiotracers. In particular, this process allowed the preparation of a range of important SPECT imaging agents, including [¹²⁵I]iomazenil, [¹²⁵I]CNS1261 and [¹²⁵I]IBOX. Also, the first radiosynthesis of a high affinity agent of TSPO which could be used to study neuroinflammation was reported. In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1Electric Literature of C6H3ClINO2).

4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Electric Literature of C6H3ClINO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Domino Suzuki coupling and condensation reaction: an efficient strategy towards synthesis of phenanthridines was written by Ghosh, Munmun;Ahmed, Atiur;Singha, Raju;Ray, Jayanta K.. And the article was included in Tetrahedron Letters in 2015.Application of 220185-63-7 This article mentions the following:

A short and convenient hetero-annulation protocol was developed for the synthesis of substituted phenanthridines via domino Suzuki coupling and condensation between N-(2-iodo-aryl)-formamide derivatives and 2-formylphenylboronic acid in the presence of Pd(OAc)₂, Cs₂CO₃ and PPh₃ as catalytic system in dry DMF at 85-90° for 6-7 h. The intermediate after Suzuki coupling and deprotection of nitrogen under the same catalytic system, furnishes the corresponding phenanthridines in good yields after immediate condensation and dehydration. In the experiment, the researchers used many compounds, for example, 4,5-Dichloro-2-iodoaniline (cas: 220185-63-7Application of 220185-63-7).

4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Application of 220185-63-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Probing hydrogen bonding to bound dioxygen in synthetic models for heme proteins: the importance of precise geometry was written by Dube, Henry;Kasumaj, Besnik;Calle, Carlos;Felber, Beatrice;Saito, Makoto;Jeschke, Gunnar;Diederich, Francois. And the article was included in Chemistry – A European Journal in 2009.HPLC of Formula: 15813-09-9 This article mentions the following:

Distal hydrogen bonding in natural dioxygen binding proteins is crucial for the discrimination between different potential ligands such as O₂ or CO. In the present study, we probe the chem. requirements for proper distal hydrogen bonding in a series of synthetic model compounds for dioxygen-binding heme proteins. The model compounds 1-Co to 7-Co bear different distal residues. The hydrogen bonding in their corresponding dioxygen adducts is directly measured by pulse EPR spectroscopy. The geometrical requirements for this interaction to take place were found to be narrow and very specific. Only two model complexes, 1-Co and 7-Co, form a hydrogen bond to bound dioxygen, which was characterized in terms of geometry and nature of the bond. The geometry and dipolar nature of this interaction in 1-Co-O₂ is more similar to the one in natural cobalt myoglobin (Co-Mb), making 1-Co the best model compound in the entire series. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9HPLC of Formula: 15813-09-9).

4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.HPLC of Formula: 15813-09-9

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Simple method for the synthesis of iodomethylbenzenes was written by Merkushev, E. B.;Sedov, A. M.;Simakhina, N. D.. And the article was included in Zhurnal Organicheskoi Khimii in 1978.Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene This article mentions the following:

P-xylene, mesitylene, durene and C₆Me₅H were treated with iodine, HNO₃ and H₂SO₄ in HOAc to give 87% 2,5-Me₂C₆H₃I and 85% 2,5-Me₂C₆H₂I₂-1,4, 88% 2,4,6-Me₃C₆H₂I, 80% 2,4,6-Me₃C₆HI₂-1,3 and 63% 1,3,5-Me₃C₆I₃, 100% 2,3,5,6-Me₄C₆HI and 88% 1,4-I₂C₆Me₄, and 87% C₆Me₅I, resp., depending on the temperature and amount of HNO₃ and H₂SO₄ used. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene).

1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

The Synthesis of 1H-Pyrazolo[3,4-b]quinoxaline Derivatives Oriented towards Modification of Carbocyclic Ring in the Parent Skeleton was written by Wojtasik, Katarzyna;Danel, Andrzej. And the article was included in ChemistrySelect in 2020.Safety of 4-Chloro-2-iodo-1-nitrobenzene This article mentions the following:

It was proved that the method of synthesis of 1H-pyrazolo[3,4-b]quinoxaline derivatives I [R¹ = 5-Cl, 6-N(Et)₂, 7-N(Et)₂, etc.] (PQX), consisting of the reductive cyclization of the corresponding pyrazole derivative II [R² = 5-Cl, 6-Cl, 7-Cl, 8-Cl] was the most universal method of PQX synthesis among the known and was regiospecific. The obtained x-chloro-1-methyl-3-phenyl-1H-pyrazolo[3,4-b]quinoxaline I [R¹ = 5-Cl, 6-Cl, 7-Cl, 8-Cl, etc.] isomers were starting materials for the synthesis of N,N-diethylamine derivatives I [R¹ = 5-N(Et)₂, 6-N(Et)₂, 7-N(Et)₂, 8-N(Et)₂, etc.]. The position differentiation of these substituents strongly impacted the emissive properties of the final compounds In the experiment, the researchers used many compounds, for example, 4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1Safety of 4-Chloro-2-iodo-1-nitrobenzene).

4-Chloro-2-iodo-1-nitrobenzene (cas: 160938-18-1) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Safety of 4-Chloro-2-iodo-1-nitrobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Schmidt Reaction of ω-Azido Valeryl Chlorides Followed by Intermolecular Trapping of the Rearrangement Ions: Synthesis of Assoanine and Related Pyrrolophenanthridine Alkaloids was written by Ding, Shao-Lei;Ji, Yang;Su, Yan;Li, Rui;Gu, Peiming. And the article was included in Journal of Organic Chemistry in 2019.Formula: C8H9IO2 This article mentions the following:

The Schmidt reaction of ω-azido valeryl chlorides in the presence of an addnl. nucleophile was explored. The arenes, alcs., and amines were demonstrated as the intermol. trapping reagents for isocyanate ion and N-acyliminium ion from the Schmidt rearrangement, affording the corresponding products with moderate to excellent yields. Two 2-oxoindoles from the reaction were successfully converted into four natural alkaloids, namely, assoanine, anhydrolycorine, oxoassoanine, and anhydrolycorinone. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Formula: C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Formula: C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ligand-Controlled Regiodivergent Hydroalkylation of Pyrrolines was written by Qian, Deyun;Hu, Xile. And the article was included in Angewandte Chemie, International Edition in 2019.Quality Control of 1-Chloro-4-iodobutane This article mentions the following:

Two series of C-alkylated pyrrolidines I [R = Boc, Cbz; R¹ = i-Pr, cyclopentyl, indol-1-yl, etc.] and II [R² = CO₂Ph, Boc, Cbz; R³ = cyclohexyl, (CH₂)₃Ph, 2-thienyl, etc.] were synthesized via ligand controlled nickel-catalyzed regiodivergent hydroalkylation of 3-pyrrolines with alkyl/aryl halides. This method demonstrated broad scope and high functional-group tolerance and could be applied in late-stage functionalizations. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Quality Control of 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Quality Control of 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Ligand-Enabled Gold-Catalyzed C(sp²)-S Cross-Coupling Reactions was written by Tathe, Akash G.;Patil, Nitin T.. And the article was included in Organic Letters in 2022.COA of Formula: C8H9IO2 This article mentions the following:

C(sp²)-S cross-coupling reactions of aryl iodides and arylsulfonyl hydrazides under ligand-enabled, Au(I)/Au(III) redox catalysis was reported. This strategy operates under mild reaction conditions, requires no prefunctionalized aryl coupling partner and works across several aryl iodides. The reaction mechanism was supported with control experiments, mass spectrometry, and NMR studies. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2COA of Formula: C8H9IO2).

4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.COA of Formula: C8H9IO2

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Elucidation of the Structure of a Highly Active Catalytic System for CO₂/Epoxide Copolymerization: A salen-Cobaltate Complex of an Unusual Binding Mode was written by Na, Sung Jae;S, Sujith;Cyriac, Anish;Kim, Bo Eun;Yoo, Jina;Kang, Youn K.;Han, Su Jung;Lee, Chongmok;Lee, Bun Yeoul. And the article was included in Inorganic Chemistry in 2009.Name: 1-Chloro-4-iodobutane This article mentions the following:

Salen-type ligands comprised of ethylenediamine or 1,2-cyclohexenediamine, along with an salicylaldehyde bearing a Me substituent on its 3-position and a -[CR(CH₂CH₂CH₂N⁺Bu₃)₂] (R=H or Me) on its 5-position, unexpectedly afford cobalt(III) complexes with uncoordinated imines. In these complexes, two salen-phenoxys and two 2,4-dinitrophenolates (DNPs), which counter the quaternary ammonium cations, coordinate persistently with cobalt, while two other DNPs are fluxional between a coordinated and an uncoordinated state in THF at room temperature The complexes of this binding mode show excellent activities in carbon dioxide/propylene oxide copolymerization (TOF, 8 300-13 000 h^-1) but with some fluctuation in induction times (1-10 h), depending on how dry the system is. The induction time is shortened (<1.0 h) and activity is increased ∼1.5 times upon the replacement of the two fluxional DNPs with 2,4-dinitrophenol-2,4-dinitrophenolate homoconjugation ([DNP···H···DNP]^–). Imposing steric congestion either by replacing the Me substituent on the salicylaldehyde with tert-Bu or by employing H₂NCMe₂CMe₂NH₂ instead of ethylenediamine or 1,2-cyclohexenediamine results in conventional imine-coordinating complexes, which show lower activities than uncoordinated imine complexes. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Name: 1-Chloro-4-iodobutane).

1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Name: 1-Chloro-4-iodobutane

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Excited-State Structure and Delocalization in Ruthenium(II)-Bipyridine Complexes That Contain Phenyleneethynylene Substituents was written by Wang, Yingsheng;Liu, Shengxia;Pinto, Mauricio R.;Dattelbaum, Dana M.;Schoonover, Jon R.;Schanze, Kirk S.. And the article was included in Journal of Physical Chemistry A in 2001.Category: iodides-buliding-blocks This article mentions the following:

A comprehensive photophys. study was carried out on the two prepared complexes [(bpy)₂Ru(4,4′-PE-bpy)]²⁺ and [(bpy)₂Ru(5,5′-PE-bpy)]²⁺ (44Ru and 55Ru, resp., where bpy = 2,2′-bipyridine and PE = phenyleneethynylene 4-Et₂NCOC₆H₄CC-). The objective of this work is to determine the effect of the phenyleneethynylene substituents on the properties of the metal-to-ligand charge-transfer excited state. The complexes were characterized by using UV-visible absorption, photoluminescence, and UV-visible and IR transient absorption spectroscopy. The results indicate that the MLCT excited state is localized on the PE-substituted bpy ligands. Also, the photophys. data indicate that in the MLCT excited state the excited electron is delocalized into the PE substituents and the manifestations of the electronic delocalization are larger when the substituents are in the 4,4′-positions. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Category: iodides-buliding-blocks).

N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Category: iodides-buliding-blocks

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com