Synthesis of 2-substituted benzo[b]furans/furo-pyridines catalyzed by NiCl2 was written by Zhou, Rong;Ding, Yanli;Yang, Mili. And the article was included in Catalysts in 2019.Formula: C6H4BrIO This article mentions the following:
A Ni-catalyzed tandem synthesis of aryl-benzo[b]furan derivatives I [X = CH, N; R1 = H, 5-Me, 5-Cl, etc.; R2 = H, 4-nPr, 4-Br, etc.] from 2-halophenols and 1-alkynes under Cu-free and phosphine-free conditions was reported. This protocol was carried out with NiCl2/5-nitro-1,10-phenanthroline in DMA at 120鎺矯 and found to be simple, cost effective, and have a wide substrate scope. Addnl., the method was compatible with heteroaryl substrates, resulted in the formation of 2-substituted benzo[b]furans/furo-pyridines I [X = N; R1 = H, 5-Me] in reasonable to good yields. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Formula: C6H4BrIO).
4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C閳ユ彂 bond is the weakest of the carbon閳ユ従alogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Formula: C6H4BrIO
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com