Pd-Catalyzed Asymmetric Intramolecular Aryl C-O Bond Formation with SDP(O) Ligand: Enantioselective Synthesis of (2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methanols was written by Shi, Jialing;Wang, Ting;Huang, Yusha;Zhang, Xinhao;Wu, Yun-Dong;Cai, Qian. And the article was included in Organic Letters in 2015.Recommanded Product: 207115-22-8 This article mentions the following:
Employing a chiral spirodiphosphine monoxide ligand with 1,1′-spirobiindane backbone I [Ar = 3,5-di(t-Bu)C6H3], a desymmetrization strategy of Pd-catalyzed intramol. asym. aryl C-O coupling of 2-(2-halophenoxy)propane-1,3-diols, was developed. The ligand I shows much better results than its SDP counterpart. The protocol provides an efficient and highly enantioselective method for the synthesis of 2-hydroxymethyl-1,4-benzodioxanes, e.g. II. D. functional theory studies provide a model that accounts for the origin of the enantioselectivity. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Recommanded Product: 207115-22-8).
4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons鑱砈mith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Recommanded Product: 207115-22-8
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com