Diamine derivatives containing imidazolidinylidenepropanedinitrile as a new class of histamine H3 receptor antagonists. Part I was written by Sasho, Setsuya;Seishi, Takashi;Kawamura, Mariko;Hirose, Ryo;Toki, Shinichiro;Shimada, Jun-ich. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Safety of 1-Chloro-4-iodobutane This article mentions the following:
Title compounds (I) were synthesized and evaluated for histamine H3 receptor-binding affinities. I [R = piperidino, n = 4; R = 2-methylpyrroldiino (Q), (S)-Q, n = 3] showed potent H3 receptor antagonism and excellent selectivity over human H1, H2 and H4 receptors. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Safety of 1-Chloro-4-iodobutane).
1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Iodo alkanes participate in a variety of organic synthesis reactions, which include the Simmons鑱砈mith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Safety of 1-Chloro-4-iodobutane
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com