New strategies in the synthesis of regioselectively trifluoromethyl- and trifluoromethoxy-substituted arenes as building blocks for biologically active molecules was written by Leconte, Stephane;Ruzziconi, Renzo. And the article was included in Journal of Fluorine Chemistry in 2002.Reference of 505084-55-9 This article mentions the following:
Regioisomerically pure trifluoromethyl- and trifluoromethoxy-substituted aromatic and heteroaromatic aldehydes and carboxylic acids are valuable building blocks for the synthesis of biol. active mols. They have been prepared by employing modern organometallic methods. On this basis, a novel access to 2,3-dihydro-5-(trifluoromethoxy)indole was developed which represents an intriguing example of how organometallic and radical chem. can fecundate each other. Iodination of [4-(trifluoromethoxy)phenyl]carbamic acid 1,1-dimethylethyl ester gave [2-Iodo-4-(trifluoromethoxy)phenyl]carbamic acid 1,1-dimethylethyl ester. Allylation of the latter gave [2-iodo-5-(trifluoromethoxy)phenyl]-2-propenylcarbamic acid 1,1-dimethylethyl ester which was cyclized to give 2,3-dihydro-3-methyl-5-(trifluoromethoxy)-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester. In the experiment, the researchers used many compounds, for example, 2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9Reference of 505084-55-9).
2-Chloro-5-(trifluoromethyl)-4-iodopyridine (cas: 505084-55-9) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Reference of 505084-55-9
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com