Azoles. Part 4. Nucleophilic substitution reactions of haloimidazoles was written by Iddon, Brian;Khan, Nazir;Lim, Bee Lan. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in 1987.Synthetic Route of C3H2I2N2 This article mentions the following:
A number of N-protected derivatives of 2,4,5-tribromoimidazole, 4-bromo-5-nitroimidazole, and 2,4-dibromo-5-nitroimidazole were prepared by standard procedures and treated with various nucleophiles. Whereas 2,4,5-tribromo (and tri-iodo)imidazole reacted with PhSNa to give 4,5-dihaloimidazoles, 1-protected derivatives of 2,4,5-tribromoimidazole reacted with RSNa (R = Et, Pr, Ph, PhCH2) in Me2CHOH, by displacement of the 2-bromine atom. 1-Benzyl-5-bromo-4-nitroimidazole, 2-(5-bromo-4-nitroimidazol-1-yl) acetate, and 5-bromo-4-nitro-1-phenacylimidazole (I) reacted by displacement of the 5-bromine atom. The product arising from reaction of I with HSCH2CO2Et in EtOH in the presence of base, cyclized to give imidazothiazine II. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Synthetic Route of C3H2I2N2).
4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Synthetic Route of C3H2I2N2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com