Synthesis and SAR studies of novel heteroaryl fused tetracyclic indole-diamide compounds: Potent allosteric inhibitors of the hepatitis C virus NS5B polymerase was written by Ding, Min;He, Feng;Hudyma, Thomas W.;Zheng, Xiaofan;Poss, Michael A.;Kadow, John F.;Beno, Brett R.;Rigat, Karen L.;Wang, Ying-Kai;Fridell, Robert A.;Lemm, Julie A.;Qiu, Dike;Liu, Mengping;Voss, Stacey;Pelosi, Lenore A.;Roberts, Susan B.;Gao, Min;Knipe, Jay;Gentles, Robert G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Category: iodides-buliding-blocks This article mentions the following:
Presented here are initial structure-activity relationship (SAR) studies on a series of novel heteroaryl fused tetracyclic indole-based inhibitors of the hepatitis C viral polymerase, NS5B. The introduction of alternative heterocyclic moieties into the indolo-fused inhibitor class significantly expands the reported SAR and resulted in the identification of pyridino analogs, typified by compounds I and II that displayed excellent potency against the NS5B polymerase of both HCV 1a and HCV 1b genotypes. In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Category: iodides-buliding-blocks).
4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Category: iodides-buliding-blocks
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com