The Asymmetric Synthesis of Amines via Nickel-Catalyzed Enantioconvergent Substitution Reactions was written by Yang, Ze-Peng;Freas, Dylan J.;Fu, Gregory C.. And the article was included in Journal of the American Chemical Society in 2021.Recommanded Product: 1-Chloro-4-iodobutane This article mentions the following:
Herein, two mild methods was reported for the catalytic enantioconvergent synthesis of protected dialkyl carbinamines such as RCHXR1 [R = i-Bu, n-hexyl, (CH2)5F, etc.; R1 = Et, i-Bu, (CH2)2Ph, etc.; X = NHBoc, Phth, NHFmoc, etc.], both of which use a chiral nickel catalyst to couple an alkylzinc reagent with α-phthalimido alkyl chloride or an N-hydroxyphthalimide (NHP) ester of a protected α-amino acid. The methods were versatile, providing dialkyl carbinamine derivatives that bear an array of functional groups. Further, for couplings of NHP esters a one-pot variant wherein the NHP ester was generated in situ, allowing the generation of enantioenriched protected dialkyl carbinamines in one step from com. available amino acid derivatives was also described. The utility of this method by applying it to the efficient catalytic enantioselective synthesis of a range of interesting target mols. was demonstrated. In the experiment, the researchers used many compounds, for example, 1-Chloro-4-iodobutane (cas: 10297-05-9Recommanded Product: 1-Chloro-4-iodobutane).
1-Chloro-4-iodobutane (cas: 10297-05-9) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Recommanded Product: 1-Chloro-4-iodobutane
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com