Simple method for the synthesis of iodomethylbenzenes was written by Merkushev, E. B.;Sedov, A. M.;Simakhina, N. D.. And the article was included in Zhurnal Organicheskoi Khimii in 1978.Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene This article mentions the following:
P-xylene, mesitylene, durene and C6Me5H were treated with iodine, HNO3 and H2SO4 in HOAc to give 87% 2,5-Me2C6H3I and 85% 2,5-Me2C6H2I2-1,4, 88% 2,4,6-Me3C6H2I, 80% 2,4,6-Me3C6HI2-1,3 and 63% 1,3,5-Me3C6I3, 100% 2,3,5,6-Me4C6HI and 88% 1,4-I2C6Me4, and 87% C6Me5I, resp., depending on the temperature and amount of HNO3 and H2SO4 used. In the experiment, the researchers used many compounds, for example, 1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene).
1,4-Diiodo-2,3,5,6-tetramethylbenzene (cas: 3268-21-1) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Recommanded Product: 1,4-Diiodo-2,3,5,6-tetramethylbenzene
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com