Li, Xiaoyan et al. published their research in Tetrahedron Letters in 2004 | CAS: 220185-63-7

4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.SDS of cas: 220185-63-7

Synthesis of optically active ring-A substituted tryptophans as IDO inhibitors was written by Li, Xiaoyan;Yin, Wenyuan;Sarma, P. V. V. Srirama;Zhou, Hao;Ma, Jun;Cook, James M.. And the article was included in Tetrahedron Letters in 2004.SDS of cas: 220185-63-7 This article mentions the following:

The first stereoselective synthesis of optically active 6-chloro-L-tryptophan, 5-nitro-D-tryptophan, 6-nitro-D-tryptophan, 5,6-dichloro-L-tryptophan, 6-aza-D-tryptophan, as well as the first synthesis of the optically active 7-methoxy-D-tryptophan with potential activity at IDO (IDO = indoleamine 2,3-dioxygenase) via the Schollkopf chiral auxiliary is described. In the experiment, the researchers used many compounds, for example, 4,5-Dichloro-2-iodoaniline (cas: 220185-63-7SDS of cas: 220185-63-7).

4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.SDS of cas: 220185-63-7

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com