Synthesis of Substituted Indole from 2-Aminobenzaldehyde through [1,2]-Aryl Shift was written by Levesque, Patrick;Fournier, Pierre-Andre. And the article was included in Journal of Organic Chemistry in 2010.Synthetic Route of C7H6INO2 This article mentions the following:
A mild, efficient, and simple method for the synthesis of 3-ethoxycarbonylindoles has been developed. Addition of Et diazoacetate (EDA) to 2-aminobenzaldehydes cleanly affords the indole core. E.g., addition of Et diazoacetate to 2-(benzylamino)-6-fluorobenzaldehyde (I) in presence of BF3.OEt2 gave 85% Et 1-benzyl-4-fluoroindole-3-carboxylate (II). As opposed to other common approaches for the synthesis of indole, this method displays both excellent functional group tolerance and perfect regiochem. control. This allowed the synthesis of a variety of useful indole building blocks from 2-aminobenzaldehydes derived from readily available anthranilic acids. In the experiment, the researchers used many compounds, for example, 2-Amino-4-iodobenzoic acid (cas: 20776-54-9Synthetic Route of C7H6INO2).
2-Amino-4-iodobenzoic acid (cas: 20776-54-9) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Synthetic Route of C7H6INO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com