Thiophene-expanded guanosine analogues of gemcitabine was written by Chen, Zhe;Ku, Therese C.;Seley-Radtke, Katherine L.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Recommanded Product: 4,5-Diiodo-1H-imidazole This article mentions the following:
The chemotherapeutic drug Gemcitabine, 2′,2′-difluoro-2′-deoxycytidine, has long been the standard of care for a number of cancers. Gemcitabine’s chemotherapeutic properties stem from its 2′,2′-difluoro-2′-deoxyribose sugar, which mimics the natural nucleoside, but also disrupts nucleic acid synthesis, leading to cell death. As a result, numerous analogs have been prepared to further explore the biol. implications for this structural modification. In that regard, a thieno-expanded guanosine analog was of interest due to biol. activity previously observed for the tricyclic heterobase scaffold. Several analogs were prepared, including the McGuigan ProTide, however the parent nucleoside exhibited the best chemotherapeutic activity, specifically against breast cancer cell lines (89.53% growth inhibition). In the experiment, the researchers used many compounds, for example, 4,5-Diiodo-1H-imidazole (cas: 15813-09-9Recommanded Product: 4,5-Diiodo-1H-imidazole).
4,5-Diiodo-1H-imidazole (cas: 15813-09-9) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Recommanded Product: 4,5-Diiodo-1H-imidazole
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com