Convergent Synthesis of Immune Inhibitor IMMH002 was written by Chen, Si;Shi, Zeyu;Xiao, Qiong;Yin, Dali. And the article was included in Synthesis in 2021.Computed Properties of C8H8BrI This article mentions the following:
A convergent synthesis of IMMH002 in 36% overall yield starting from bromobenzene was described with a key Suzuki-Miyaura cross-coupling reaction used to provide a crucial intermediate. The route does not require column chromatog. and solves the most intractable quality problem caused by a homolog byproduct in the original linear synthesis. Furthermore, reducing the use of Lewis acid mediated reactions improves the environmental impact of the synthesis and reduces overall waste. The new route described herein was more efficient, convenient, reliable, and economically more viable when compared to the previously reported linear route. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9Computed Properties of C8H8BrI).
1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Computed Properties of C8H8BrI
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com