Catalytic, asymmetric difluorination of alkenes to generate difluoromethylated stereocenters was written by Banik, Steven M.;Medley, Jonathan William;Jacobsen, Eric N.. And the article was included in Science (Washington, DC, United States) in 2016.Synthetic Route of C8H7IO4 This article mentions the following:
Difluoromethyl groups possess specific steric and electronic properties that invite their use as chem. inert surrogates of alcs., thiols, and other polar functional groups important in a wide assortment of mol. recognition processes. We report here a method for the catalytic, asym., migratory geminal difluorination of β-substituted styrenes to access a variety of products bearing difluoromethylated tertiary or quaternary stereocenters. The reaction uses com. available reagents (m-chloroperbenzoic acid and hydrogen fluoride pyridine) and a simple chiral aryl iodide catalyst and is carried out readily on a gram scale. Substituent effects and temperature-dependent variations in enantioselectivity suggest that cation-π interactions play an important role in stereodifferentiation by the catalyst. In the experiment, the researchers used many compounds, for example, Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7Synthetic Route of C8H7IO4).
Methyl 3,5-dihydroxy-4-iodobenzoate (cas: 338454-02-7) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Synthetic Route of C8H7IO4
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com