C-H functionalization of amines with aryl halides by nickel-photoredox catalysis was written by Ahneman, Derek T.;Doyle, Abigail G.. And the article was included in Chemical Science in 2016.SDS of cas: 77350-52-8 This article mentions the following:
Synthesis of phenylpyrrolidines e.g., I via functionalization of α-amino C-H bonds with aryl halides using a combination of nickel and photoredox catalysis was described. This direct C-H, C-X coupling uses inexpensive and readily available starting materials to generate benzylic amines, an important class of bioactive mols. Mechanistically, this method features the direct arylation of α-amino radicals mediated by a nickel catalyst. This reactivity was demonstrated for a range of aryl halides and N-aryl amines, with orthogonal scope to existing C-H activation and photoredox methodologies. Reactions with several complex aryl halides, demonstrating the potential utility of this approach in late-stage functionalization was also reported. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8SDS of cas: 77350-52-8).
N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.SDS of cas: 77350-52-8
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com