Electrophile-Mediated Reactions of Functionalized Propargylic Substrates was written by Urbanaite, Aurelija;Jonusis, Mantas;Buksnaitiene, Rita;Balkaitis, Simonas;Cikotiene, Inga. And the article was included in European Journal of Organic Chemistry in 2015.Formula: C8H9IO2 This article mentions the following:
Metal-free halogen, chalcogen, or (oxo)carbenium ion mediated yne-carbonyl or yne-thioxo transformations of a range of N- and O-propargylic compounds have been studied. This investigation has led to the development of a mild, economic, and effective method for the synthesis of functionalized 4H-1,3-oxazines, 4H-1,3-thiazines, 4,5-dihydrothiazoles, and α-substituted enones. The structure of the propargylic substrate and the nature of electrophile influence both the outcome and regioselectivity of processes. The synthesis of the target compounds was achieved using propargyl compounds as starting materials, such as N-[3-(4-methoxyphenyl)-2-propynyl]benzamide (alkyne-amide), N-[3-(4-methoxyphenyl)-2-propynyl]carbamic acid dimethylethyl ester (alkyne-carbamate), N-[3-(4-methoxyphenyl)-2-propynyl]-N‘-(phenylmethyl)urea (alkyne-urea). In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Formula: C8H9IO2).
4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Formula: C8H9IO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com