Deoxyfluorination of alcohols with 3,3-difluoro-1,2-diarylcyclopropenes was written by Li, Lingchun;Ni, Chuanfa;Wang, Fei;Hu, Jinbo. And the article was included in Nature Communications in 2016.Product Details of 5460-32-2 This article mentions the following:
The use of 3,3-difluoro-1,2-diarylcyclopropenes (CpFluors) I (Ar = 2-methoxyphenyl, naphth-1-yl, 2,4-dimethoxyphenyl, etc.) as easily accessible and reactivity-tunable deoxyfluorination reagents has been reported. The electronic nature of CpFluors is critical for fluorination of monoalcs. such as (R)-1-(4-bromophenylsulfonyl)pyrrolidin-3-ol, 2-(naphthalen-1-yl)ethan-1-ol, 4-(3-methylphenyl)butan-2-ol, etc. via alkoxycyclopropenium cations, and CpFluors with electron-rich aryl substituents facilitate the transformation with high efficiency. The selective monofluorination of 1,2- and 1,3-diols, such as syn-cyclohexane-1,2-diol, 2,2-dimethylpropane-1,3-diol, (2R,3S)-butane-2,3-diol, etc. which proceeds via cyclopropenone acetals, is less dependent on the electronic nature of CpFluors. Moreover, CpFluors are more sensitive to the electronic nature of alcs. than many other deoxyfluorination reagents, thus fluorination of longer diols can be achieved selectively at the relatively electron-rich position. This research not only unveils the first example of deoxyfluorination reagents that contain an all-carbon scaffold, but also sheds light on the divergent reactivity of cyclopropenium cation in deoxyfunctionalization of alcs. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Product Details of 5460-32-2).
4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.Product Details of 5460-32-2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com