Quadruple C-H activation coupled to hydrofunctionalization and C-H silylation/borylation enabled by weakly coordinated palladium catalyst was written by Tang, Bo-Cheng;Lin, Wen-Xuan;Chen, Xiang-Long;He, Cai;Ma, Jin-Tian;Wu, Yan-Dong;Lan, Yu;Wu, An-Xin. And the article was included in Nature Communications in 2020.Synthetic Route of C6H3F2I This article mentions the following:
A quadruple C-H activation cascade as well as hydro-functionalization, C-H silylation/borylation sequence based on weakly coordinated palladium catalyst was reported . The hydroxyl group modulated the intrinsic direction of the Heck reaction, and then acts as an interrupter that biases the reaction away from the classic β-H elimination and toward C-H functionalization. Mechanistically, d. functional theory calculation provides important insights into the key six-membered oxo-palladacycle intermediates, and indicates that the β-H elimination was unfavorable both thermodynamically and kinetically. In this article, the versatility of this approach, which was a strategic expansion of the Heck reaction was focused. In the experiment, the researchers used many compounds, for example, 1,2-Difluoro-3-iodobenzene (cas: 64248-57-3Synthetic Route of C6H3F2I).
1,2-Difluoro-3-iodobenzene (cas: 64248-57-3) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Organoiodine lubricants can be used with titanium, stainless steels, and other metals which tend to seize up with conventional lubricants: organoiodine lubricants can be used in turbines and spacecraft, and as a cutting oil in machining.Synthetic Route of C6H3F2I
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com