Carbo-Carboxylation of Alkenes via Intramolecular Heck Carbonylation Utilizing CO2 and Hydrosilane was written by Wang, Meng-Meng;Lu, Sheng-Mei;Li, Can. And the article was included in ACS Catalysis in 2022.Quality Control of 4-Bromo-2-iodophenol This article mentions the following:
Starting from diverse alkene-tethered aryl halides 2-X-3-R-4-R1-5-R2C6HYZ(CH2)nC(=CH2)R3 [R = H, OMe, Cl; R1 = H, Me, t-Bu, Br, F, Cl; R2 = H, OMe, Cl, COOMe; R3 = Me, n-Bu, methoxymethyl; X = Br, I; Y = Z = O, CH2; n = 0, 1] and silyl formate formed in situ from CO2 and PMHS (polymethylhydrosiloxane), the carbo-carboxylation of alkenes has been achieved using an easily accessible Pd/monophosphine ligand combination as the catalyst. This protocol provides competent access to construct a series of 2,3-dihydrobenzofurans, chromans, isochroman, indanes and tetralins bearing a β-acid moiety I in moderate to excellent yield. Addnl., the example of domino carbo-carbonylation reactions has been demonstrated using diene-tethered aryl iodide as starting material, forming oxygen-containing bicyclic products I in good yield. It is speculated that the carbo-carboxylation reaction of alkenes proceeds via a carbo-silyloxycarbonylation pathway. In the experiment, the researchers used many compounds, for example, 4-Bromo-2-iodophenol (cas: 207115-22-8Quality Control of 4-Bromo-2-iodophenol).
4-Bromo-2-iodophenol (cas: 207115-22-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Quality Control of 4-Bromo-2-iodophenol
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com