Direct Synthesis of Methylene-Bridged Bis-biaryl Carboxylates via Cascade Suzuki Coupling and CH2Cl2-Based Bis-esterification was written by Xiong, Jin;Zhong, Guofeng;Zou, Lianghua;Liu, Yunyun. And the article was included in ChemistrySelect in 2018.Application of 13420-63-8 This article mentions the following:
The synthesis of bis-biaryl carboxylates such as I [R1 = H, 4-Me, 3-Cl, 3-F; R2 = H, 4-CH3, 4-Cl, etc.] were designed via Pd-catalyzed multicomponent cascade Suzuki coupling and bis-esterification of iodobenzoic acids, arylboronic acids with dichloromethane. The present work offered a direct and practical route to the synthesis of novel carboxylate scaffolds with extended diversity. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-iodobenzoic acid (cas: 13420-63-8Application of 13420-63-8).
2-Chloro-6-iodobenzoic acid (cas: 13420-63-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I.Application of 13420-63-8
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com