A facile synthesis of various fluorine-containing indole derivatives via palladium-catalyzed annulation of internal alkynes was written by Chae, Jungha;Konno, Tsutomu;Ishihara, Takashi;Yamanaka, Hiroki. And the article was included in Chemistry Letters in 2004.Safety of 4,5-Dichloro-2-iodoaniline This article mentions the following:
The palladium-catalyzed annulation reaction of a variety of fluorine-containing internal alkynes with 2-iodoaniline derivatives took place smoothly to give the corresponding 2,3-disubstituted indoles, e.g., I, in good to excellent yields. In the experiment, the researchers used many compounds, for example, 4,5-Dichloro-2-iodoaniline (cas: 220185-63-7Safety of 4,5-Dichloro-2-iodoaniline).
4,5-Dichloro-2-iodoaniline (cas: 220185-63-7) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Safety of 4,5-Dichloro-2-iodoaniline
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com