Synthesis of 3-[4(5)-imidazolylmethyl]-2-methylbenzoic acid, a metabolite of the drug detomidine was written by Cardin, Christine J.;Convery, Maire A.;Kavanagh, Pierce V.;Lambert, Michael T. B.;McKenna, Brian;McMurray, T. Brian H.. And the article was included in Journal of Chemical Research, Synopses in 1992.Reference of 133232-56-1 This article mentions the following:
The synthesis of the title compound I (R = H, R1 = CO2H, X = H2), a metabolite of detomidine I (R = H, R1 = Me, X = H2), is reported. A key step of the synthesis is the Grignard reaction of iodobenzyl alc. derivative II with 1-tritylimidazole-4-carboxaldehyde to give I (R = CPh3, R1 = CH2OCH2OMe, X = H, OH), which was converted in 6 steps to the title compound The crystal structure of I (R = H, R1 = CO2Me, X = H,H) was determined In the experiment, the researchers used many compounds, for example, 3-Iodo-2-methylbenzoic acid (cas: 133232-56-1Reference of 133232-56-1).
3-Iodo-2-methylbenzoic acid (cas: 133232-56-1) belongs to iodide derivatives. In general, organic iodides are light-sensitive and turn yellow during storage, owing to the formation of iodine. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Reference of 133232-56-1
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com