Adasme-Carreno, Francisco et al. published their research in RSC Advances in 2016 | CAS: 64248-57-3

1,2-Difluoro-3-iodobenzene (cas: 64248-57-3) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Recommanded Product: 1,2-Difluoro-3-iodobenzene

Halogen bonding in drug-like molecules: a computational and systematic study of the substituent effect was written by Adasme-Carreno, Francisco;Munoz-Gutierrez, Camila;Alzate-Morales, Jans H.. And the article was included in RSC Advances in 2016.Recommanded Product: 1,2-Difluoro-3-iodobenzene This article mentions the following:

Halogen bonding (XB) is a noncovalent interaction that has been increasingly used in mol. recognition, and more recently, in protein-ligand binding. We have studied and quantified, using d. functional theory (DFT) calculations, the substituent effect of fourteen chem. groups in the chloro-, bromo- and iodobenzene···N-methylacetamide (NMA) complexes, which serve as a model of a common arrangement of XB in biol. systems. A total of 126 halobenzene···NMA complexes have been optimized and examined regarding their relative energy, mol. electrostatic potential, topol. anal. of electron d. and charge transfer. The extent of substituent effect was found to be up to 1.5 kcal mol-1, where electron-withdrawing groups increase the XB strength while electron-donating substituents reduce it. Excellent statistical correlations (R2 > 0.9) were obtained for the comparison between XB interaction energy and the computed electronic properties (electron d., mol. electrostatic potential, and NBO charges), suggesting that the substituent effect was mainly due to the electrostatic interaction, and resonance effects were negligible. Furthermore, a pos. cooperativity effect, in the strengthening of the XB, was observed in NMA complexes with di-, tri- and tetrafluoro-iodobenzenes. In the experiment, the researchers used many compounds, for example, 1,2-Difluoro-3-iodobenzene (cas: 64248-57-3Recommanded Product: 1,2-Difluoro-3-iodobenzene).

1,2-Difluoro-3-iodobenzene (cas: 64248-57-3) belongs to iodide derivatives. Generally organic iodides can be divided into two classes of alkyl iodides and aryl iodides. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Recommanded Product: 1,2-Difluoro-3-iodobenzene

Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com