Facile synthesis of 2-iodo-spiro[indene-1,1′-isobenzofuran]-3′-ones via iodine-promoted cascade cyclization was written by Zhu, Hai-Tao;Dong, Xue;Wang, Li-Jing;Zhong, Mei-Jin;Liu, Xue-Yuan;Liang, Yong-Min. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2012.Application of 13420-63-8 This article mentions the following:
Iodospiroindeneisobenzofuranones such as I (R = I) were prepared in 49-99% yields by regioselective iodine-mediated cascade cyclization of diarylhydroxypropynylbenzoates such as II (R1 = Me, Et, Me2CH, Me3C, PhCH2) in 1,2-dichloroethane at ambient temperature Diarylhydroxypropynylbenzoates with different aryl groups on the propynyl alc. moiety gave the corresponding iodospiroindeneisobenzofuranones with some regioselectivity. I (R = I) underwent Sonogashira, Suzuki, and Heck reactions with phenylacetylene, styrene, and 4-methoxyphenylboronic acid to give I (R = PhCC), I [R = (E)-PhCH:CH], and I (R = 4-MeOC6H4) in 74%, 86%, and 99% yields, resp. The structures of I and of an isopropenyliodoisobenzopyranone formed from iodocyclization of a methylhydroxybutynylbenzoate were determined by X-ray crystallog. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-iodobenzoic acid (cas: 13420-63-8Application of 13420-63-8).
2-Chloro-6-iodobenzoic acid (cas: 13420-63-8) belongs to iodide derivatives. Organoiodine compounds occur widely in organic chemistry, but are relatively rare in nature. Iodo alkanes participate in a variety of organic synthesis reactions, which include the SimmonsSmith reaction (cyclopropanation using iodomethane), Williamson ether synthesis, Wittig reaction, Grignard reaction, alkyl coupling reactions, and Wurtz reaction.Application of 13420-63-8
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com