Mode of action and quantitative structure-activity correlations of tuberculostatic drugs of the isonicotinic acid hydrazide type was written by Seydel, Joachim K.;Schaper, Klaus J.;Wempe, Ellen;Cordes, Hans P.. And the article was included in Journal of Medicinal Chemistry in 1976.Safety of 2-Iodopyridine-4-carboxylic acid This article mentions the following:
Quant. structure-activity studies were made for 18 isoniazid (I) [54-85-3] 2-substituted derivatives by correlating electronic, steric, and lipophilic properties of the substituents with biol. activity from dilution tests with Mycobacterium tuberculosis. The reaction rates for the quaternization of corresponding 2-substituted pyridines with MeI gave rate constants showing a dependence on steric and electronic effects of substituents similar to the effects on the bactericidal activities of the I derivatives The correlations indicate that reactivity of the pyridine [110-86-1] N is essential for biol. activity of the I derivatives, and that the I derivatives are incorporated into an NAD analog. In the experiment, the researchers used many compounds, for example, 2-Iodopyridine-4-carboxylic acid (cas: 58481-10-0Safety of 2-Iodopyridine-4-carboxylic acid).
2-Iodopyridine-4-carboxylic acid (cas: 58481-10-0) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. A typical method for synthesis of aromatic iodides is diazotization of primary aromatic amines followed by treatment of potassium iodide. Aliphatic alcohols are converted to alkyl iodides by treating with hydrogen iodide.Safety of 2-Iodopyridine-4-carboxylic acid
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com