Palladium-Catalyzed ortho-Halogenation of Tertiary Benzamides was written by Qiu, Fang-Cheng;Yang, Wen-Cheng;Chang, Yong-Zhen;Guan, Bing-Tao. And the article was included in Asian Journal of Organic Chemistry in 2017.Recommanded Product: N,N-Diethyl-4-iodobenzamide This article mentions the following:
A general and efficient protocol for the synthesis of ortho-halogenated tertiary benzamides under mild conditions was described. Benzamides with various functional groups underwent ortho-iodination, bromination or chlorination with NXS using a cationic palladium catalyst generated in-situ from Pd(OAc)2 and TfOH in DME. Given the generality, efficiency, mild conditions and readily available catalyst and halogenation reagents, this method provided a practical approach for the synthesis of ortho-halogenated benzamides. In the experiment, the researchers used many compounds, for example, N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8Recommanded Product: N,N-Diethyl-4-iodobenzamide).
N,N-Diethyl-4-iodobenzamide (cas: 77350-52-8) belongs to iodide derivatives. Organic iodides are organic compounds containing a carbon-iodine (C-I) bond. The carbon-iodine bond is weaker than other carbon-halogen bonds due to the poor electronegative nature of the iodine atom. The C–I bond is the weakest of the carbon–halogen bonds. These bond strengths correlate with the electronegativity of the halogen, decreasing in the order F > Cl > Br > I. This periodic order also follows the atomic radius of halogens and the length of the carbon-halogen bond.Recommanded Product: N,N-Diethyl-4-iodobenzamide
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com