A Regioselective Approach to C3-Aroylcoumarins via Cobalt-Catalyzed C(sp2)-H Activation Carbonylation of Coumarins was written by Pashazadeh, Rahim;Rajai-Daryasarei, Saideh;Mirzaei, Siyavash;Soheilizad, Mehdi;Ansari, Samira;Shabanian, Meisam. And the article was included in Synthesis in 2019.COA of Formula: C8H9IO2 This article mentions the following:
A new cobalt-catalyzed C-H bond activation of coumarins I (R = H, 6-Me, 7-OMe, 6-Cl, 6-Br) with aryl halides or pseudohalides R1X (R1 = Ph, 4-methylphenyl, thiophen-2-yl, etc.; X = I, Br, OTf) and carbon monoxide insertion to give various 3-aroylcoumarin derivatives II is described. It is the first time that CO as C1 feedstock is used as the coupling partners in cobalt-catalyzed regioselective coumarin C-H functionalization reactions. Upon activation with manganese powder, the Co catalyzes the C-H bond activation carbonylation reactions of aryl iodides, bromides, and even triflates under mild conditions, providing the regioselective aroylated products II in moderate to good yields. In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2COA of Formula: C8H9IO2).
4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Typical reactions of alkyl iodides include nucleophilic substitution, elimination, reduction, and the formation of organometallics. Polyiodoorganic compounds are sometimes employed as X-ray contrast agents, in fluoroscopy, a type of medical imaging. This application exploits the X-ray absorbing ability of the heavy iodine nucleus.COA of Formula: C8H9IO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com