Cross-Coupling of [2-Aryl-1,1,2,2-tetrafluoroethyl](trimethyl)silanes with Aryl Halides was written by O’Duill, Miriam;Dubost, Emmanuelle;Pfeifer, Lukas;Gouverneur, Veronique. And the article was included in Organic Letters in 2015.Synthetic Route of C8H9IO2 This article mentions the following:
The synthesis of arylCF2CF2SiMe3 and their reactivity in cross-coupling reactions with aryl iodides and aryl bromides to afford a range of 1,1,2,2-tetrafluoro-1,2-diarylethanes is reported. The use of pyridine as an alternative to phenanthroline, and the ability to carry out the reaction at 60 °C or room temperature are the key features of this Cu-Ag mediated cross-coupling methodol. The chem. is compatible with (hetero)aryl halides, offering a platform to develop products of interest in material and medicinal chem. Thus, e.g, cross-coupling of silane I with aryl iodide II under optimized conditions consisting of CuI (1 equiv), AgF (1.5 equiv) and pyridine (5.0 equiv) in DMSO at 60° for 6 h afforded III (76%). In the experiment, the researchers used many compounds, for example, 4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2Synthetic Route of C8H9IO2).
4-Iodo-1,2-dimethoxybenzene (cas: 5460-32-2) belongs to iodide derivatives. Organic iodides can be alkyl, alkenyl, or alkynyl, and all of them are very reactive toward with many kinds of nucleophiles. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Synthetic Route of C8H9IO2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com