Cross-coupling reaction of 2-(1,3-butadienyl)magnesium chloride with alkyl or aryl halides by lithium chloride-cupric chloride (Li2CuCl4), a superior catalyst was written by Nunomoto, Sadaaki;Kawakami, Yuhsuke;Yamashita, Yuya. And the article was included in Journal of Organic Chemistry in 1983.Category: iodides-buliding-blocks This article mentions the following:
The combination of lithium chloride-cupric chloride (Li2CuCl4) was an excellent catalyst in selective cross-coupling reaction of 2-(1,3-butadienyl)magnesium chloride with alkyl or aryl halides. The order of reactivities for the halides was I > Br > Cl, and alkyl halides > aryl halides and primary halides ≫ secondary halides. N-alkyl bromides and iodides especially exhibited high reactivities in the coupling reactions. In the experiment, the researchers used many compounds, for example, 1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9Category: iodides-buliding-blocks).
1-Bromo-4-(2-iodoethyl)benzene (cas: 85356-68-9) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Category: iodides-buliding-blocks
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com