Regio- and chemoselective metalation of chloropyrimidine derivatives with TMPMgCl·LiCl and TMP2Zn·2MgCl2·2LiCl was written by Mosrin, Marc;Knochel, Paul. And the article was included in Chemistry – A European Journal in 2009.Formula: C4H2ClIN2 This article mentions the following:
Efficient zincation and magnesiation of chlorinated pyrimidines can be performed at convenient temperatures (e.g., 25 and 55°C) by using TMPMgCl·LiCl and TMP2Zn·2MgCl2·2LiCl (TMP = 2,2,6,6-tetramethylpiperidyl) as effective bases. Quenching of the resulting zincated or magnesiated pyrimidines with various electrophiles furnishes highly functionalized pyrimidines in 51-93 % yield. Oxidative aminations were carried out, thus leading to aminated pyrimidines. By using this methodol., we have also prepared pharmaceutically relevant pyrazolopyrimidines and the fungicide Mepanipyrim. In the experiment, the researchers used many compounds, for example, 2-Chloro-4-iodopyrimidine (cas: 395082-55-0Formula: C4H2ClIN2).
2-Chloro-4-iodopyrimidine (cas: 395082-55-0) belongs to iodide derivatives. Iodide-containing intermediates are common in organic synthesis, because of the easy formation and cleavage of the C–I bond. Alkyl iodides react at a faster rate than alkyl fluorides due to the weak C-I bond.Formula: C4H2ClIN2
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com