PdII-catalyzed monoselective ortho halogenation of C-H bonds assisted by counter cations: a complementary method to directed ortho lithiation was written by Mei, Tian-Sheng;Giri, Ramesh;Maugel, Nathan;Yu, Jin-Quan. And the article was included in Angewandte Chemie, International Edition in 2008.Quality Control of 2-Chloro-6-iodobenzoic acid This article mentions the following:
The yield and selectivity of monoselective ortho halogenation of benzoic acid derivatives were improved greatly by using tetraalkyl ammonium salts as additives. These effects are attributed to the influence of counter cations. The halogenated products are versatile intermediates for the construction of substituted aromatic compounds In the experiment, the researchers used many compounds, for example, 2-Chloro-6-iodobenzoic acid (cas: 13420-63-8Quality Control of 2-Chloro-6-iodobenzoic acid).
2-Chloro-6-iodobenzoic acid (cas: 13420-63-8) belongs to iodide derivatives. Organic iodides are widely used in organic synthesis. Halogenation of aromatic hydrocarbons is a very important reaction via an electrophilic aromatic substitution. In the chemical industry, alkyl iodides serve as excellent alkylating agents and, specifically, methyl iodide is used as a methylating agent in the synthesis of various pharmaceutical drugs.Quality Control of 2-Chloro-6-iodobenzoic acid
Referemce:
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com